Electrochemical Oxidation of Flavonoids and Interaction with DNA on the Surface of Supramolecular Ionic Liquid Grafted on Graphene Modified Glassy Carbon Electrode

نویسندگان

  • Fahimeh Tavakolyan Pour Department of Chemistry, Faculty of Science, Science & Research Branch, Islamic Azad University, Tehran, I.R. IRAN
  • Hossein Rastegar Food and Drug Control Reference Laboratories, 408-Valiasr Street, Tehran, I.R. IRAN
  • Mohammad Saber Tehrani Department of Chemistry, Faculty of Science, Science & Research Branch, Islamic Azad University, Tehran, I.R. IRAN
  • Parviz Abroomand Azar Department of Chemistry, Faculty of Science, Science & Research Branch, Islamic Azad University, Tehran, I.R. IRAN
  • Syed Waqifhusain Department of Chemistry, Faculty of Science, Science & Research Branch, Islamic Azad University, Tehran, I.R. IRAN
چکیده مقاله:

The study of the interaction between DNA and small molecules such as drugs is one of the current general interest and importance. In this paper, the electrochemical investigation of the interaction between some flavonoids such as rutin, quercetin, and hesperidin with dsDNA on the surface of Supramolecular Ionic Liquid grafted on the Graphene Oxide Modified Glassy Carbon Electrode (SIL-GO/GCE) is reported for the first time. The apparent binding constant (K) of the interaction between flavonoids and dsDNA was calculated using the current titrations. The apparent binding constants (K) of rutin, quercetin and hesperidin were calculated to be 4.3×105, 2.1×105 and 9.2×1-6 M-1, respectively. Furthermore, the electrochemical behavior of rutin on the surface of SIL-GO/GCE was studied in details using cyclic voltammetry and linear sweep voltammetry.  The mechanism of the electrochemical redox reaction of rutin was proposed. When DNA was added into flavonoid solutions, their cathodic peak currents were decreased with few changes in the peak potentials. Furthermore, the interaction between rutin and bovine serum albuminwas studied using differential pulse voltammetry. In conclusion, the SIL-GO/GCE provides a promising platform for the study of the interaction between DNA and small molecules.

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عنوان ژورنال

دوره 37  شماره 3

صفحات  117- 125

تاریخ انتشار 2018-06-01

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